Journal of Medicinal Chemistry
Volume 40, Issue 7 (March 28, 1997)
Copyright © 1997 American Chemical Society

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1049-1062

Structure-Activity Studies for a Novel Series of N-(Arylethyl)-N-(1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-N-methylamines Possessing Dual 5-HT Uptake Inhibiting and 2-Antagonistic Activities Michael D. Meyer, Arthur A. Hancock, Karin Tietje, Kevin B. Sippy, Rajnandan Prasad, David M. Stout, David L. Arendsen, B. Greg Donner, and William A. Carroll [Full Article - PDF]

1063-1074

Structure-Activity Relationships in a Series of Orally Active -Hydroxy Butenolide Endothelin Antagonists William C. Patt, Jeremy J. Edmunds, Joseph T. Repine, Kent A. Berryman, Billy R. Reisdorph, Chet Lee, Mark S. Plummer, Aurash Shahripour, Stephen J. Haleen, Joan A. Keiser, Mike A. Flynn, Kathleen M. Welch, Elwood E. Reynolds, Ron Rubin, Brian Tobias, Hussein Hallak, and Annette M. Doherty [Full Article - PDF]

1075-1089

Synthesis and Structure-Activity Relationships of Carboxylated Chalcones: A Novel Series of CysLT1 (LTD4) Receptor Antagonists Mariël E. Zwaagstra, Hendrik Timmerman, Masahiro Tamura, Tsutomu Tohma, Yasushi Wada, Kazuhiro Onogi, and Ming-Qiang Zhang [Full Article - PDF]

1090-1098

Preparation, DNA Binding, and in Vitro Cytotoxicity of a Pair of Enantiomeric Platinum(II) Complexes, [(R)- and (S)-3-Aminohexahydroazepine]dichloro- platinum(II). Crystal Structure of the S Enantiomer Ronald R. Fenton,1a Warren J. Easdale,1b H. Meng Er,1a Shaun M. O'Mara,1b Mark J. McKeage,1b Pamela J. Russell,1b and Trevor W. Hambley,1a [Full Article - PDF]

1099-1103

Synthesis and Pharmacological Characterization of Enantiomerically Pure Muscarinic Agonists: Difluoromuscarines Piero Angeli, Franco Cantalamessa, Roberto Cavagna, Paola Conti, Marco De Amici, Carlo De Micheli, Anna Gamba, and Gabriella Marucci [Full Article - PDF]

1104-1111

Cytotoxicity and Antiestrogenicity of a Novel Series of Basic Diphenylethylenes Jacques Gilbert, Maryse Fuentes, Tiiu Ojasoo, Jean-Christophe Doré, and Michel Pons [Full Article - PDF]

1112-1129

19-Nor-10-azasteroids: A Novel Class of Inhibitors for Human Steroid 5-Reductases 1 and 2 Antonio Guarna, Catherine Belle, Fabrizio Machetti, Ernesto G. Occhiato, and Andrew H. Payne , Chiara Cassiani, Alessandra Comerci, Giovanna Danza, Alessandra De Bellis, Stefania Dini, Alessandro Marrucci, and Mario Serio [Full Article - PDF]

1130-1135

Structure-Based Design of a Potent, Selective, and Irreversible Inhibitor of the Catalytic Domain of the erbB Receptor Subfamily of Protein Tyrosine Kinases Juswinder Singh, Ellen M. Dobrusin, David W. Fry, Taraneh Haske, Adrian Whitty, and Dennis J. McNamara [Full Article - PDF]

1136-1148

Reliability of Comparative Molecular Field Analysis Models: Effects of Data Scaling and Variable Selection Using a Set of Human Synovial Fluid Phospholipase A2 Inhibitors Angel R. Ortiz, Manuel Pastor, Albert Palomer, Gabriele Cruciani, Federico Gago, and Rebecca C. Wade [Full Article - PDF]

1149-1164

Structure-Based Design of Nonpeptidic HIV Protease Inhibitors: The Sulfonamide-Substituted Cyclooctylpyranones Harvey I. Skulnick, Paul D. Johnson, Paul A. Aristoff, Jeanette K. Morris, Kristine D. Lovasz, W. Jeffrey Howe, Keith D. Watenpaugh, Musiri N. Janakiraman, David J. Anderson, Robert J. Reischer, Theresa M. Schwartz, Lee S. Banitt, Paul K. Tomich, Janet C. Lynn, Miao-Miao Horng, Kong-Teck Chong, Roger R. Hinshaw, Lester A. Dolak, Eric P. Seest, Francis J. Schwende, Bob D. Rush, Gina M. Howard, Lisa N. Toth, Karen R. Wilkinson, Thomas J. Kakuk, Carol W. Johnson, Serena L. Cole, Renee M. Zaya, Gail L. Zipp, Peggy L. Possert, Robert J. Dalga, Wei-Zhu Zhong, Marta G. Williams, and Karen R. Romines [Full Article - PDF]

1165-1168

4-Substituted Cubylcarbinylamines: A New Class of Mechanism-Based Monoamine Oxidase B Inactivators Joseph J. P. Zhou, Jianchang Li, Suhbash Upadhyaya, Philip E. Eaton, and Richard B. Silverman [Full Article - PDF]

1169-1172

Minor Structural Differences in Boc-CCK-4 Derivatives Dictate Affinity and Selectivity for CCK-A and CCK-B Receptors Kazumi Shiosaki, Chun Wel Lin, Hana Kopecka, Bruce Bianchi, Thomas Miller, Michael Stashko, and David Witte [Full Article - PDF]

1173-1177

Effect of N9-Methylation and Bridge Atom Variation on the Activity of 5-Substituted 2,4-Diaminopyrrolo[2,3-d]pyrimidines against Dihydrofolate Reductases from Pneumocystis carinii and Toxoplasma gondii1a,b Aleem Gangjee, Farahnaz Mavandadi, and Sherry F. Queener [Full Article - PDF]

1178-1178

Deciphering the Chemical Code By Nicolaos D. Epiotis. VCH Publishers Inc., New York. 1996. xlvii + 933 pp. 16.5 × 24 cm. ISBN 1-56081-946-4. $89.95. Lemont B. Kier [Full Article - PDF]

1178-1178

Computer-Aided Molecular Design. Theory and Applications By Jean-Pierre Doucet and Jacques Weber. Academic Press Ltd., London. 1996. xix + 487 pp. 17.5 × 24.5 cm. ISBN 0-12-221285-1. $55.00. Glen E. Kellogg [Full Article - PDF]